I went ahead and purchased ESET's NOD32 version 3. It has a little larger footprint than the older version, but it is still small in comparison to other front-runners. Get the business version if you do not want the entire suite with a firewall, etc.
I can tell you that it is fast and reliable. It helped me clean a kids laptop that was infected with Vuntu, a task that Symantec could not do. Updates are fast and always on time (every hour, by default). It catches spyware, even ones that seem harmless. This product has my vote.
The business version comes with a central console that you can push installs, updates and even uninstall the clients with. All told, a very worthy product.
They have a trial version you can download, so go see for yourself.
http://eastnetworks.com/blog/htsrv/trackback.php/34
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